Position: Postdoctoral Researcher


Principal investigator: Esther Castellano


Project: MycoMatrix – Engineering of a Recombinant Live Biotherapeutic to Normalize Tumor Extracellular Matrix in KRAS-driven NSCLC


Location: Instituto de Biología Molecular y Celular del Cáncer, Salamanca, Spain


Duration: 3 years


Funding: Colaboración Público-Privada Program


Consortium Partners: Pulmobiotics and Vall d’Hebron Institut de Recerca


Are you a motivated scientist with expertise in parasitic bacteria, especially Mycoplasma, and a strong background in molecular biology? Join our dynamic research team in Salamanca, Spain, working on the MycoMatrix project to work with engineered live biotherapeutic for KRAS-driven Non-Small Cell Lung Cancer (NSCLC).


Project Overview: The MycoMatrix project, funded by the Colaboración Público-Privada Program, is a collaboration between Pulmobiotics and Vall d’Hebron Institut de Recerca. The goal of the project is to engineer a recombinant live biotherapeutic to normalize the tumor extracellular matrix in KRAS-driven NSCLC, advancing cancer treatment strategies by modifying the tumor microenvironment.


Position Details: As a Postdoctoral Researcher on the MycoMatrix project, you will: generate CAF-derived ECM and grow engineered Mycoplasma, to characterize the role of engineered live biotherapeutics in the tumor microenvironment; Cultivate, maintain and characterize 3D cell co-cultures to mimic the tumour microenvironment; Conduct molecular and cellular experiments to evaluate biotherapeutic efficacy; Utilize fluorescence and confocal microscopy for visualizing cellular processes; Employ flow cytometry for high-throughput analysis of cell populations; Collaborate closely with a diverse team of scientists from the lab and the consortium; Contribute to scientific publications and presentations.



  • Ph.D. in a relevant field (e.g., Microbiology, Cell Biology, Molecular Biology) – Mandatory
  • Expertise in parasitic bacteria, specifically Mycoplasma
  • Experience in tissue culture techniques, including 3D cultures
  • Experience in molecular and cellular biology methodologies
  • Familiarity with fluorescence and confocal microscopy.
  • Competence in flow cytometry.
  • Enthusiastic, motivated, and dedicated to advancing cancer research.


How to Apply

Interested candidates should submit the following materials by 15th October 2023:

CV highlighting relevant qualifications and experience.

Cover Letter describing your research interests and why you are a suitable candidate.

Contact information for three professional references.

Please email your application to ecastellano@usal.es with the subject line “MycoMatrix Postdoc Application – [Your Name].”


Join us in advancing cancer research and therapy. We look forward to receiving your application and welcoming a passionate researcher to our team.